HSV antivirals – current and future treatment options

Publication date: June 2016 Source:Current Opinion in Virology, Volume 18 Author(s): Alexander Birkmann, Holger Zimmermann Herpes simplex virus (HSV) types 1 and 2 can cause infections with clinical manifestations ranging from benign and generally self-limiting blisters or sores as seen in labial and genital herpes through to severe and in rare cases even life-threatening infections. At present, approved treatments for herpes simplex virus are almost all nucleoside analogs. Novel antiviral approaches include therapeutic vaccines, with the most advanced having successfully completed Phase 2 clinical development. Moreover, several small molecules approaches are being developed for the treatment of genital or labial HSV infections...

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Herpes Mastitis: Diagnosis and Management

We report two cases about simultaneous mammary and extramammary (oral and genital) herpetic infection in nonlactating women. In both cases, HSV breast lesions were acquired by sexual contacts with partners who were asymptomatic HSV carriers. Through a review of literature, we highlight clinical signs for an early diagnosis. We also emphasize the advantage of the valacyclovir for treating this uncommon pathology. (Source: The Breast Journal)
MedWorm: Genital Herpes

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‘Vaginal seeding’ may put newborns at risk of infection

"’Vaginal seeding’ of babies born by C-section could pose infection risk," The Guardian reports.  The practice of exposing babies born by caesarean section to their mother’s vaginal fluid in an effort to boost their immunity may actually lead to an infection, experts say. Vaginal seeding involves rubbing vaginal fluid on the baby with the intention of exposing it to the "healthy" bacteria it would be exposed to in a vaginal birth. However, there is no evidence the practice is effective, and it runs the risk of babies developing serious infections from potentially harmful bacteria or viruses mothers may be unaware they are carrying. The most effective and safe way you can improve your baby’s immunity is through breastfeeding. Where did the story come from? Doct…
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Status of vaccine research and development of vaccines for herpes simplex virus prepared for WHO PD-VAC.

Authors: Johnston C, Gottlieb SL, Wald A Abstract Herpes simplex virus type-1 (HSV-1) and -2 (HSV-2) are highly prevalent global pathogens which commonly cause recurrent oral and genital ulcerations. Less common but more serious complications include meningitis, encephalitis, neonatal infection, and keratitis. HSV-2 infection is a significant driver of the HIV epidemic, increasing the risk of HIV acquisition 3 fold. As current control strategies for genital HSV-2 infection, including antiviral therapy and condom use, are only partially effective, vaccines will be required to reduce infection. Both preventive and therapeutic vaccines for HSV-2 are being pursued and are in various stages of development...

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Novel therapeutic investigational strategies to treat severe and disseminated HSV infections suggested by a deeper understanding of in vitro virus entry processes.

Authors: Clementi N, Criscuolo E, Cappelletti F, Burioni R, Clementi M, Mancini N Abstract The global burden of herpes simplex virus (HSV) legitimates the critical need to develop new prevention strategies, such as drugs and vaccines that are able to fight either primary HSV infections or reactivations. Moreover, the ever-growing number of patients receiving transplants increases the number of severe HSV infections that are unresponsive to current therapies. Finally, the high global incidence of genital HSV-2 infection increases the risk of perinatal transmission to newborns, in which disseminated infection or central nervous system (CNS) involvement is frequent, with associated high morbidity and mortality rates...

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First HSV-1 Non Primary Genital Herpes in two patients

Although HSV-1 has become a common cause of primary genital herpes, the two cases we report are, to our knowledge, the first documented first episodes of HSV-1 genital herpes in patients in whom there is evidence of prior HSV-2 infection. Beyond proving that this situation is possible, they call forth the following questions: why had such cases not been documented before, are they indeed rare? if so why? are prior encounters with one herpes simplex genotype protective against the other? (Source: Journal of Clinical Virology)
MedWorm: Genital Herpes

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Men on Tinder think they have a ‘license to use unattractive women as they see fit’

Men on Tinder think they have a “licence to use women as they see fit” if their date’s appearance is less attractive than her profile photograph, research says.
Sexual Health / STDs News From Medical News Today

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Perianal Herpes Simplex Virus Infection Misdiagnosed With Pyoderma Gangrenosum: Case of the Month from the Case Consultation Committee of the International Society for the Study of Vulvovaginal Disease

No abstract available (Source: Journal of Lower Genital Tract Disease)
MedWorm: Genital Herpes

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Study finds addiction associated with poor awareness of others

Study with adolescents finds dose-response relationship between substance use and sensitivity to others.
Sexual Health / STDs News From Medical News Today

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Prevalence of genital herpes in HIV positive patients attending STI clinic at a tertiary care hospital and its correlation with CD4 counts

Background: HIV infection is emerging as one of the major health problems faced by the clinicians across the world, more so because of co-existence of many sexually transmitted infections (STIs) among HIV infected patients. The presence of untreated STIs (both ulcerative and non-ulcerative) increases the risk of both acquisition and transmission of HIV by a factor of upto 10 times. Recurrent and persistent ulcerative HSV2 lesions are among the common infections in HIV patients. Prevalence of genital herpes has increased markedly between the 1970’s and 1990’s. (Source: International Journal of Infectious Diseases)

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MedWorm: Genital Herpes

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