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Oral and Vaginal Tenofovir for Genital Herpes Simplex Virus Type 2 Shedding in Immunocompetent Women: A Double-Blind, Randomized, Cross-over Trial

Conclusions. Oral TDF modestly decreased HSV shedding and lesion rate, and quantity of virus shed when used consistently. Vaginal TFV gel decreased quantity of virus shed by 60%. In contrast to effects on HSV-2 acquisition, tenofovir is unlikely to provide clinically meaningful reductions in the frequency of HSV shedding or genital lesions. Clinical Trials Registration. NCT01448616 (Source: The Journal of Infectious Diseases)
MedWorm: Genital Herpes

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Hepatitis C: Signs and Symptoms

Hepatitis C (HCV) affects thousands of Americans each year. Learn all about the signs and symptoms of the condition here, as well as treatment options.
Sexual Health / STDs News From Medical News Today

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School sex education often negative, heterosexist, and out of touch

And taught by poorly trained, embarrassed teachers, say young people.School sex education is often negative, heterosexist, and out of touch, and taught by poorly trained, embarrassed teachers…
Sexual Health / STDs News From Medical News Today

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Induction of interferon-{lambda} contributes to TLR3 and RIG-I activation-mediated inhibition of herpes simplex virus type 2 replication in human cervical epithelial cells

We examined the expression of toll-like receptors (TLRs) and retinoic acid-inducible I (RIG-I) in End1/E6E7 cells by real-time PCR. The IFN- induced by TLR3 and RIG-I activation of End1/E6E7 cells was also examined by real-time PCR and ELISA. HSV-2 infection of End1/E6E7 cells was evaluated by the real-time PCR detection of HSV-2 gD expression. The antibody to IL-10Rβ was used to determine whether IFN- contributes to TLR3/RIG-I mediated HSV-2 inhibition. Expression of interferon regulatory factor 3 (IRF3), IRF7, IFN-stimulated gene 56 (ISG56), 2′-5′-oligoadenylate synthetase I (OAS-1) and myxovirus resistance A (MxA) were determined by the real-time PCR and western blot. End1/E6E7 cells were transfected with shRNA to knockdown the IRF3, IRF7 or RIG-I expression. Student’s t-test and p…

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Greater efforts are needed to eliminate female genital mutilation

The World Health Organization reports that more than 200 million girls and women currently have been subjected to female genital mutilation/cutting worldwide, and three million girls continue to be…
Sexual Health / STDs News From Medical News Today

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Sexual problems more common among young women after heart attack

Younger women between ages 18-55 years are more likely than men to experience sexual function problems in the year following a heart attack, study finds.
Sexual Health / STDs News From Medical News Today

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WHO revise STD treatment guidelines as threat of antibiotic resistance escalates

Prompted by rapidly increasing resistance to antibiotics, the WHO have revised treatment guidelines for three STDs: gonorrhea, syphilis, and chlamydia.
Sexual Health / STDs News From Medical News Today

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High Rate of β-Globin DNA Detection Validates Self-Sampling in Herpes Simplex Virus Shedding Studies

Conclusions: Human β-globin DNA detection rate was high, and the quantity obtained significantly increased with genital, but not oral HSV shedding. The high rate of β-globin DNA detection is consistent with high adherence to study procedures in longitudinal studies of genital herpes shedding. (Source: Sexually Transmitted Diseases)
MedWorm: Genital Herpes

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