Herpes simplex virus type 2 (HSV-2) genital shedding in HSV-2-/HIV-1-co-infected women receiving effective combination antiretroviral therapy

The dynamics of genital shedding of HSV-2 DNA was assessed in HIV-1-infected women taking combination antiretroviral therapy (cART). HIV-1 RNA, HIV-1 DNA and HSV DNA loads were measured during 12–18 months using frozen plasma, PBMC and cervicovaginal lavage samples from 22 HIV-1-infected women, including 17 women naive for antiretroviral therapy initiating cART and 5 women with virological failure switching to a new regimen. Nineteen (86%) women were HSV-2-seropositive. Among HSV-2-/HIV-1-co-infected women, HIV-1 RNA loads showed a rapid fall from baseline after one month of cART, in parallel in paired plasma and cervicovaginal secretions. In contrast, HIV-1 DNA loads did not show significant variations from baseline up to 18 months of treatment in both systemic and genital compartme…
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Unfortunate synergy between HIV and genital herpes.

Authors: PMID: 26884529 [PubMed – in process] (Source: Canadian Family Physician Medecin de Famille Canadien)
MedWorm: Genital Herpes

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Soft-core pornography may fuel negativity toward women, endorse rape myths

People who frequently view soft-core pornography – such as images of semi-naked women – may have less positive attitudes toward women, say researchers.
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Taking PDE5 inhibitors for erectile dysfunction unlikely to increase risk of skin cancer

Three drugs widely prescribed for erectile dysfunction are unlikely to increase risk of malignant melanoma, according to a study published in the journal PLOS Medicine.
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Stunting at 5 Years Among SGA Newborns

CONCLUSIONS: Etiological subgroups of SGA differed in risk of stunting at 5 years. SGA newborns of inadequate GWG mothers who smoke and SGA newborns of short mothers were at particularly high risk of stunting. (Source: PEDIATRICS)
MedWorm: Genital Herpes

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Cigarette smoking in high school at ‘all-time low,’ CDC report

The CDC have announced that cigarette smoking among high school students has fallen to its lowest level since 1991. Concerns remains about e-cigarette use.
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Boredom keeps sex workers on the streets

Bad housing, poor support and even boredom are some reasons stopping women quitting or ‘transitioning out of’ sex work, a new study reveals.
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Same-sex relations ‘not wrong at all,’ say half of Americans

A study reveals a fundamental shift among Americans in attitude toward and willingness to engage in same-sex relations over the last 40 years.
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[Research Articles] Mathematical modeling of herpes simplex virus-2 suppression with pritelivir predicts trial outcomes

Pharmacokinetic and pharmacodynamic models estimate the potency of antiviral agents but do not capture viral and immunologic factors that drive the natural dynamics of infection. We designed a mathematical model that synthesizes pharmacokinetics, pharmacodynamics, and viral pathogenesis concepts to simulate the activity of pritelivir, a DNA helicase-primase inhibitor that targets herpes simplex virus. Our simulations recapitulate detailed viral kinetic shedding features in five dosage arms of a phase 2 clinical trial. We identify that in vitro estimates of median effective concentration (EC50) are lower than in vivo values for the drug. Nevertheless, pritelivir potently decreases shedding at appropriate doses based on its mode of action and long half-life...

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Teenage pregnancies hit record low, reflecting efforts of England’s strategy to reduce under-18 conceptions

Rates of teenage pregnancy in England have halved since the implementation of the Government’s Teenage Pregnancy Strategy (TPS) in 1999, and the greatest effect is seen in areas of high deprivation…
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