Pharmacokinetic and pharmacodynamic models estimate the potency of antiviral agents but do not capture viral and immunologic factors that drive the natural dynamics of infection. We designed a mathematical model that synthesizes pharmacokinetics, pharmacodynamics, and viral pathogenesis concepts to simulate the activity of pritelivir, a DNA helicase-primase inhibitor that targets herpes simplex virus. Our simulations recapitulate detailed viral kinetic shedding features in five dosage arms of a phase 2 clinical trial. We identify that in vitro estimates of median effective concentration (EC50) are lower than in vivo values for the drug. Nevertheless, pritelivir potently decreases shedding at appropriate doses based on its mode of action and long half-life...Read More
Correlates of African American female adolescent offenders 3, 4-Methylenedioxymethamphetamine (MDMA or “Ecstasy”) use and sexually transmitted infection morbidity. J Hum Behav Soc Environ. 2016;26(2):194-201 Authors: Stephens T, Holliday RC, Hopkins S, Rose S, Braithwaite R, Smith S Abstract The current study was designed to determine the extent to which self-reported ecstasy use in a population of juvenile adolescent detainees in a southern state is associated with high-risk health behaviors pertaining to sexually transmitted infection (STI) symptomology and past history of STI occurrence. Participants were 764 African American females extracted from an overall sample of 2,260 juvenile offenders housed at selected Youth Development Campuses in the state of Georgia...Read More
Authors: Parent D Abstract Exclude herpes infection in the presence of acute oral ulcers of unknown origin, particularly in patients in poor general condition. Remember that asymptomatic HSV-1 shedding in saliva may result in an oral-genital transmission. Perform an anogenital examination and a screening for other sexually transmitted diseases when oral warts are diagnosed. Search for immunosuppression and monitor the patient (screening for a potential associated carcinoma) when there is rapid growth of oral warts. Consider all the clinical signs (systemic, skin, other mucosa, immunity…) when a patient has an enanthem or oral ulcerations. Ask for a HIV test when an oral Kaposi’s sarcoma, a hairy leukoplakia or major aphthae are diagnosed...Read More
CONCLUSION: This study shows the usefulness of a topographic approach in the diagnosis of dermatoses of the glans penis in Korea. The findings could be used as baseline data for establishing an accurate diagnosis in Koreans. PMID: 26848217 [PubMed] (Source: Annals of Dermatology)
MedWorm: Genital Herpes
is a synthetic purine nucleoside analogue antiviral agent with activity against herpes simplex virus types 1 (HSV-1), genital herpes virus (HSV-2), and varicella-zoster virus (VZV). [#] [#] (Source: Aids Info Drugs)
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Publication date: April 2016 Source:Current Opinion in Virology, Volume 17 Author(s): Johanna Katharina Kaufmann, Jessica Baker Flechtner Immunotherapeutic vaccines have emerged as a novel treatment modality for genital herpes, a sexually transmitted disease mainly caused by herpes simplex virus type 2. The approaches to identify potential vaccine antigens have evolved from classic virus attenuation and characterization of antibody and T cell responses in exposed, but seronegative individuals, to systematic screens for novel T cell antigens. Combined with implementation of novel vaccine concepts revolving around immune evasion and local recruitment of immune effectors, the development of a safe and effective therapeutic vaccine is within reach...Read More