Prevalence of herpes simplex virus type 2 decreases among pregnant women in the Pacific Northwest

In a research study that consisted of approximately 15,000 expectant ladies, seroprevalence of herpes simplex infection (HSV) kind 2 lessened substantially between 1989 and 2010 while there was no total reduce …
Sexual Wellness / STDs Information From Medical News Today

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Role of the infections in recurrent spontaneous abortion.

Writers: Nigro G, Mazzocco M, Mattia E, Carlo di Renzo G, Carta G, Anceschi MM Embryo-fetal infections have been reported to induce persistent unplanned abortions (RSAs) at a rate less than 4 %. The possible systems include manufacturing of poisonous metabolic byproducts, fetal or placental infection, persistent endometrial infection, and chorio-amnionitis. Viruses look the most often involved pathogens, since several of them can produce persistent or recurring maternal infection. Specifically, cytomegalovirus while pregnant can get to the placenta by viremia, adhering to both main and recurrent infection, or by ascending course from the cervix, primarily following awakening...

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Immunization with Herpes Simplex Virus Type 2 (HSV-2) Genes Plus Inactivated HSV-2 Is Highly Protective Against Acute and Recurrent HSV-2 Disease.

In this research study, we evaluated a DNA prime- formalin-inactivated virus (FI-HSV2) improvement injection strategy in the guinea pig model of severe and reoccurring HSV-2 genital condition. Five groups of guinea porkers were vaccinated and intravaginally challenged with HSV-2. 2 teams were topped with plasmid DNAs encoding the secreted kind of glycoprotein D2 (gD2t) along with two genes needed for viral duplication, either helicase (UL5) and DNA polymerase (UL30) or solitary stranded DNA binding protein (UL29) and primase (UL52). Both DNA primed teams were enhanced with FI-HSV2 produced with monophosphoryl lipid A (MPL) and alum adjuvants. Two additional groups were keyed with the vacant backbone plasmid DNA (pVAX)...

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Identification of novel virus-specific antigens by CD4(+) and CD8(+) T cells from asymptomatic HSV-2 seropositive and seronegative donors.

Authors: Long D, Skoberne M, Gierahn TM, Larson S, Price JA, Clemens V, Baccari AE, Cohane KP, Garvie D, Siber GR, Flechtner JB Abstract Reactivation of latent herpes simplex virus 2 (HSV-2) infections can be characterized by episodic recurrent genital lesions and/or viral shedding. We hypothesize that infected (HSV-2(pos)) asymptomatic individuals have acquired T cell responses to specific HSV-2 antigen(s) that may be an important factor in controlling their recurrent disease symptoms. Our proteomic screening technology, ATLAS™, was used to characterize the antigenic repertoire of T cell responses in infected (HSV-2(pos)) and virus-exposed seronegative (HSV-2(neg)) subjects...

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Treatment of Genital Herpes Simplex

MR. BRIGGS is a pharmacist clinical specialist, Outpatient Clinics, Memorial Care Center for Women at Miller Children’s Hospital, Long Beach, Calif.; a clinical professor of pharmacy at the University of California, San Francisco; and an adjunct professor of pharmacy at the University of Southern California, Los Angeles. He also is a fellow of the American College of Clinical Pharmacy, coauthor of “Drugs, Pregnancy, and Lactation,” and coeditor of “Diseases, Complications, and Drug Therapy in Obstetrics.” He had no disclosures related to the topic of this column. (Source: Ob.Gyn. News)
MedWorm: Genital Herpes

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Screening of Herpes simplex virus 2 infection among pregnant women in southern China.

We analyzed 1740 sera accumulated from expecting women matured 21-39 years, making use of enzyme-linked immunosorbent assay for the detection of specific antitoxins against HSV-2. The general prevalence of HSV-2 infection was 23.56 % (95 % confidence interval [CI]=21.53-26.00). The occurrance of HSV-2 infection in the females with unusual pregnancy was 35.93 % (95 % CI=26.23-42.44) (83/231), which was much above that in women who had been pregnant just before but without irregular maternity and that in the primipara team. (P(0.05). The presence of HSV-2 antibodies was likewise linked with status of education and learning. The frequency of HSV-2 infection in the 26-30-year age team (27.49 %) (95 % CI=24.53-30.33) was the greatest amongst any age groups...

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Anal sex between young men and women often seems coercive and painful

Anal sex between boys and women commonly seems forceful and uncomfortable, recommends study released in the on-line journal BMJ Open.
Sexual Wellness / STDs News From Medical Information Today

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Innate and adaptive immunity against herpes simplex virus type 2 in the genital mucosa

Abstract: Herpes simplex virus type 2 (HSV-2) is becoming increasingly prevalent worldwide, despite the widespread use of antiviral drugs. Its ability to evade the immune system and establish a latent infection has made it difficult to develop an effective vaccine. Our understanding of the immune response against HSV-2 remains complex and involves a balance between innate signaling pathways and the adaptive immune response. Primary infection with HSV-2 induces toll-like receptor (TLR)-mediated Type I interferon (IFN) production, which establishes an antiviral state and activates multiple cell types, including natural killer cells and plasmacytoid dendritic cells...

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Sexually transmitted diseases during pregnancy: a synthesis of particularities

As doenças sexualmente transmissíveis (DSTs) apresentam prevalência significativa tanto na população geral quanto nas gestantes. Nestas, em especial, devem-se considerar as alterações fisiológicas em seu organismo que podem, inclusive, alterar o curso dessas doenças. Complicações obstétricas e neonatais podem ocorrer em decorrência delas, acarretando aumento da morbimortalidade materno-infantil. Abordam-se, neste artigo, as particularidades da história natural e terapêutica no período gestacional das principais DSTs: cancro mole, donovanose, gonorreia, clamidíase, hepatites virais, herpes genital, infecção pelo papilomavírus humano (HPV), linfogranuloma venéreo, sífilis e vulvovaginites...

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Genital ulcerations due to a cowpox virus: A misleading diagnosis of herpes.

Authors: Dina J, Lefeuvre PF, Bellot A, Dompmartin-Blanchère A, Lechapt-Zalcman E, Freymuth F, Vabret A PMID: 21324734 [PubMed - as provided by author] (Source: Herpes)

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MedWorm: Genital Herpes

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